We have led landmark studies in the fields of TB case finding, TB preventive therapy and TB-HIV integration. These included those evaluating TB preventive therapy (Thibela INH study), done in three large-scale mining regions, and TB diagnosis (XTEND evaluation) that have had implications for global policy and practice. Other large cluster-randomized trials have evaluated TB/HIV integration interventions such as the use of presumptive TB treatment for ART patients (TB FastTrack), use of TB/HIV integration officers in clinics (MERGE) and introduction of INH and Point of care CD4 in households for contact tracing (Inhibit TB).